Retinoids, vitamin A derivatives–such as retinol, retinal, retinaldehyde, adapalene, and others–have long held a celebrated place in many skincare routines.

They work by encouraging cell turnover, helping the fresh, healthy-looking skin beneath the surface replace older, duller cells. Over time, consistent use can lead to firmer skin, improved tone, and reduced fine lines and wrinkles. Their revitalizing properties even helped launch the modern anti-aging skincare revolution.

But here’s the thing: Retinoids come with baggage.

The Downside of Retinoids

Retinoids are notorious for causing irritation, especially during the “break-in” period. They increase photosensitivity, making your skin more vulnerable to sun damage. They’re also not pregnancy-safe. Even worse, they don’t play well with others: Pairing retinoids with other active ingredients like AHAs, BHAs, PHAs, or vitamin C often results in flaky, irritated skin and a compromised skin barrier, cue the burning and stinging.

And if that’s not enough, many dermatologists recommend waiting 20 minutes after applying retinoids before layering anything else on top. It’s a delicate, multi-step process that can make even the most dedicated skincare lover question their commitment.

So Why Do People Still Use Them?

Because when they work, they really work. Consistent retinoid use can reduce wrinkles and fine lines by up to 24% and improve elasticity and firmness by 30%. That’s far more potent than many of the so-called “hero” ingredients that have surfaced in recent years. Vitamin C may help boost sun protection, hyaluronic acid is great for plumping the skin, and niacinamide is effective at reducing hyperpigmentation. But none of them rival retinoids in reversing visible signs of aging. Even peptides, despite the growing hype, haven’t come close in efficacy.

The Fragility Factor

Retinoids also degrade surprisingly quickly. Exposure to air and light can reduce their potency dramatically, even before you’ve opened the bottle. Some formulations lose up to 30% of their effectiveness within weeks of opening. Despite all these challenges, retinoids have continued to dominate the anti-aging skincare category.

But that was then, and this is now.

Meet twentyfour skincare: the Retinoid Alternative 

twentyfour’s age-reversing products target the root cause of aging—mitochondrial dysfunction—24 hours a day with a single application. How?
Enter Y100™, a patented, all-natural extract from the amla tree, that we combined with Z-pods®, a sustained-release delivery system. Together, they deliver a level of potency and effectiveness that significantly surpasses retinoids….without the baggage.

In clinical testing, twentyfour skincare reduced wrinkles and fine lines by 58%, improved elasticity by 50%, enhanced firmness by 48%, smoothed skin texture by 47%, evened skin tone by 23%, and boosted brightness by 20%. These are standout numbers, well above what’s typically seen with retinoids.

So, what’s the catch?

That’s the thing, there isn’t one. The twentyfour lineup of products are suitable for all skin types. They blend seamlessly into existing routines, layer effortlessly with other actives, and come with no known irritation. They’re also pregnancy-safe, cruelty-free, and 100% vegan. No break-in period. No stinging. No flaking. Just results.

Targeting the Root Cause of Skin Aging

Even more impressive, Y100 doesn’t just address the surface signs of aging, it targets the cellular root cause. Mitochondrial dysfunction has now been identified as the primary driver of skin aging, thanks to groundbreaking research by Dr. K. Singh, Professor and Head of the Integrative Center of Aging Research at the University of Alabama at Birmingham. His findings were published in Cell Death & Disease, part of the Nature family of journals.

To act on this discovery, Dr. Singh and his colleagues launched YuvaBio. Using AI to screen over 14,000 compounds (including various retinoids, hyaluronic acid, and vitamin C), they identified the most promising agents for reversing mitochondrial decline. Y100 emerged as the top performer.

Recognizing that the compound’s effectiveness needed a delivery system that could sustain activity throughout the day, YuvaBio turned to Zylö Therapeutics, developers of the patented Z-pod® system from Einstein College of Medicine. Together, they ensured that Y100’s benefits would last over 24 hours, maintaining mitochondrial activity and delivering consistent skin-rejuvenating power all day long.

Real Results, Backed by Science

After seeing promising lab results, YuvaBio tested the Y100-loaded Z-pods in a clinical study conducted by the world’s largest Contract Research Organization. The outcomes were nothing short of remarkable, outperforming retinol, hyaluronic acid, and every other major active ingredient aimed at reversing skin aging.

And unlike retinoids, these results came without irritation, without photosensitivity, and without complication.

This is what modern skincare looks like: effective, gentle, science-backed, and simple.
Getting to the root of the skin-aging process on a 24/7 basis can do wonders for your skin. Are you ready to see the results for yourself? It’s time to experience twentyfour skincare.

Z-pod® is a registered trademark of Zylö Therapeutics Inc. and Y100™ is a trademark owned by YuvaBiosciences Inc.